Organic Letters

ORGANIC LETTERS NaIO4-Mediated Selective Oxidative Halogenation of Alkenes and Aromatics Using cornerstone Metal Halides 2003 Vol. 5, No. 23 4501-4504 Gajanan K. Dewkar, Srinivasarao V. Narina, and Arumugam Sudalai* chemic Engineering and wreak DeVelopment DiVision, National Chemical Laboratory, Pashan Road, Pune 411008, India sudalai@dalton.ncl.res.in authentic September 21, 2003 plagiarize NaIO4 oxidizes alkali metal halides efficiently in aqueous long suit to halogenate alkenes and aromatics and produce the corresponding halo derivatives in excellent regio and stereoselectivity. The melodious arrangement also demonstrates the asymmetric version of bromo hydroxylation using ?-cyclodextrin complexes, resulting in moderate ee. The 1,2-functionalization of olefins by the selective addition of two diverse functional groups, such as water or alcohols and halogens (halohydroxylation or haloalkoxylation), in a highly regio- and enantioselective manner, mud important and ambitious to organic chemists.1 Such halo derivatives are wide employ in the implication of pharmaceuticals, dyes, flame-retardants, additives and plasticizers, agrochemicals, and speciality chemicals.2 Conventional halogenation methods3 typically habit elemental halogens, which are pollutants, and generate hazardous HX as byproducts.

Recently, the aerobic halogenation of olefins by metal halides has emerged as an important option for the synthesis of such * To whom correspondence should be addressed. Phone: +91-0205893300. Fax: + 91-20-5893359. (1) Tenaglia, A.; Pardigon, O.; Buono, G. J. Org. Chem. 1996, 61, 11291132. Haruyoshi, M.; K iyoshi, T.; Masahiro, N.; Akira, H.; Yutaka,! N.; Yasutaka, I. J. Org. Chem. 1994, 59, 5550-5555. Rodriguez, J.; Dulcere, j.-P. tax deduction 1993, 1177-1205. Block, E.; Schwan, A. L. In ComprehensiVe Organic Synthesis; Trost, B. M., Fleming, I., Semmelhack, M. F., Eds.; Pergamon Press: Oxford, 1991; Vol. 4, pp 344-347. (2) Ullmanns Encyclopedia Of Industrial Chemistry, 6th ed.;...If you want to get a full essay, order it on our website: BestEssayCheap.com

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